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The key to an effective nutraceutical supplement is that the ingredients have substantial scientific research supporting the health claims made by the manufacturer. Our main ingredients Astaxanthin, Curcumin C3 Complex, CBD/CBG and Thymoquinone all have either significant clinical studies and/or in-Vitro and in-Vivo research to support their health benefits.

COVID-19 VIRUS
Coronavirus Disease 2019 (COVID-19) can induce an extreme immune response characterized by the overproduction of immune cells and the uncontrolled release of pro-inflammatory cytokines. Exceedingly high levels of the cytokines IL-1, IL-6, IL-8, TNF-a, and CRP result in overt inflammatory symptoms that include mild to severe respiratory disease, high fever, and cough. In progressed disease this “cytokine storm” will circulate throughout the body to trigger a surge of active immune cells into the lungs resulting in acute lung injury and acute respiratory distress syndrome (ARDS) and may be particularly severe in immune compromised subjects such as the elderly, diabetics, and those with cardiovascular disease. (Cardax, 2020) https://cardaxpharma.com/coronavirus/

Principi, N., Bosis, S., & Esposito, S. (2010). Effects of coronavirus infections in children. Emerging infectious diseases, 16(2), 183–188. https://doi.org/10.3201/eid1602.090469 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957994/

ASTAXANTHIN

Research #1
• Astaxanthin has been shown to downregulate neuroinflammation (via ERK-, MSK-, and NF-κB-mediated signals) in activated microglia https://www.ncbi.nlm.nih.gov/pubmed/20932499

Research #2
• Astaxanthin has been shown to enhance adult hippocampal neurogenesis and spatial memory in mice https://www.ncbi.nlm.nih.gov/pubmed/26643409

Research #3
• Astaxanthin has been shown to reduce blood pressure, maintain blood vessel elasticity, improve blood flow, and support healthy blood chemistry (numerous studies including https://www.jstage.jst.go.jp/article/jaam/6/4/6_4_15/_pdf )

Research #4
• The Protective Effects of Astaxanthin on the OVA-Induced Asthma Mice Model. The exposure of the mice to astaxanthin attenuated their airway inflammation and reduced the levels of IgE and IgG1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150233/

Research #5
• Reactive oxygen species (ROS) play a crucial role in the inflammatory response and cytokine outbreak, such as during virus infections, diabetes, cancer, cardiovascular diseases, and neurodegenerative diseases. Astaxanthins are the best antioxidant for ROS-burst-mediated acute diseases, like avian influenza infection and ischemia-reperfusion. https://www.hindawi.com/journals/omcl/2016/6859523/

Research #6
• Early clinical trials demonstrate that astaxanthin can improve cognitive impairment and memory-related problems in particular. Astaxanthin-rich (6 – 12 mg) algae supplementation may improve cognitive function https://supplementsinreview.com/nootropic/astaxanthin-nootropic/

Research #7
• The researchers concluded that “astaxanthin-rich Haematococcus pluvial is extract improves cognitive function in the healthy aged individuals.” Astaxanthin (6 – 12 mg) may help fight dementia https://www.jstage.jst.go.jp/article/jcbn/advpub/0/advpub_D-11-00017/_article/-char/ja/

CANNABINOIDS
Research #1
• What is CBG (Cannabigerol) & what does this cannabinoid do? https://www.leafly.com/news/cannabis-101/what-is-cbg-cannabinoid

Research #2
• CBD has been shown to reduce reactive gliosis and the neuroinflammatory response as well as to promote neurogenesis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289988/

Research #3
• Several studies showed that cannabinoids downregulate cytokine and chemokine production and, in some models, upregulate T-regulatory cells (Tregs) as a mechanism to suppress inflammatory responses. The endocannabinoid system is also involved in immunoregulation. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/

Research #4
• Cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470879/)

CURCUMIN C3 COMPLEX
Research #1
• Clinical studies of Curcumin C3 report numerous health benefits, including antioxidant & anti-inflammatory activity, improvement of arthritis, alleviation of inflammatory & autoimmune conditions, anxiolytic activity, immunomodulatory activity, and improvement of metabolic syndrome-related health measures such as blood cholesterol levels. https://supplementsinreview.com/brand/curcumin-c3-complex/

Research #2
• This randomized, double-blind, placebo-controlled study examined the efficacy of Curcumin C3 for arthritis. A total of 40 people with knee osteoarthritis (OA) were given curcumin extract (1.5 g) daily in 3 doses or placebo for 6 weeks.
Compared to placebo, the curcumin group experienced improvement on the McMaster Universities Arthritis Index (WOMAC) score, particularly in terms of pain and physical function.
The researchers concluded that “…curcuminoids represent an effective and safe alternative treatment for OA.” Curcumin C3 (1.5 g) appears to improve osteoarthritis https://www.ncbi.nlm.nih.gov/pubmed/24853120

Research #3
• This randomized, double-blind study examined the potential antidepressant and anxiolytic (anxiety-reducing) effects of Curcumin C3 in obese individuals. A total of 30 obese people were given placebo or curcumin extract (1 g) daily for 30 days. Although the study did not find any changes in measures of depression, the Beck Anxiety Inventory (BAI) scale improved with curcumin supplementation, suggesting an anxiolytic effect.
The researchers concluded that “Curcumin has a potential anti-anxiety effect in individuals with obesity.” Curcumin C3 (1 g) may reduce anxiety in obese individuals https://www.ncbi.nlm.nih.gov/pubmed/25776839

Research #4
• This randomized, placebo-controlled study evaluated the effects of Curcumin C3 on abnormal blood lipid levels. A total of 100 people with metabolic syndrome were given curcumin (1 g plus 10 mg Bioperine for improved absorption) or placebo daily for 8 weeks. Compared to placebo, curcumin supplementation reduced LDL (“bad”) cholesterol, total cholesterol, triglycerides and lipoprotein(a), while increasing HDL (“good”) cholesterol.
The researchers concluded that “Curcuminoids-Bioperine combination is an efficacious adjunctive therapy in patients with MS and can modify serum lipid concentrations…” https://www.ncbi.nlm.nih.gov/pubmed/25440375

Research #5
• Curcumin C3 combines curcuminoids from turmeric with Bioperine from black pepper to enhance absorption. Curcumin C3 with Bioperine (10 mg) appears to improve levels of cholesterol and other blood lipids
This randomized, double-blind, placebo-controlled, crossover study looked at the effects of Curcumin C3 on dyslipidemia in obese individuals. A total of 30 obese participants were given placebo or curcuminoids (1 g) daily for 30 days. The supplementation significantly lowered blood triglyceride levels but had no effect on other blood lipid parameters such as total cholesterol.
The researchers concluded that “…curcuminoid supplementation (1 g/day for 30 days) leads to a significant reduction in serum triglycerides concentrations…” Curcumin C3 (1 g) may lower elevated triglyceride levels in obese individuals
The researchers concluded that “curcumin may exert immunomodulatory effects via altering the circulating concentrations of IL-1β, IL-4, and VEGF.” Curcumin C3 (1 g) may reduce markers of inflammation and immune system dysfunction in obese individuals https://www.ncbi.nlm.nih.gov/pubmed/22610853

Research #6
• This randomized, double-blind, placebo-controlled study evaluated the effects of Curcumin C3 on oxidative stress in diabetes. A total of 118 people with type 2 diabetes were given placebo or curcumin (1 g plus 10 mg Bioperine for better absorption) daily for 8 weeks. The supplementation increased blood antioxidant capacity and activity of the antioxidant enzyme superoxide dismutase (SOD), while reducing MDA, a marker of oxidative stress.
The researchers concluded that “The present results support an antioxidant effect of curcuminoids supplementation in patients with T2DM.” Curcumin C3 (1 g) with Bioperine (10 mg) appears to reduce oxidative stress in diabetes https://www.ncbi.nlm.nih.gov/pubmed/24678280

Research #7
• This randomized, double-blind, placebo-controlled trial investigated the effects of Curcumin C3 on adiponectin and leptin – two hormones that play important roles in the development of obesity and diabetes. A total of 117 people with metabolic syndrome were given placebo or curcumin (1 g) daily for 8 weeks. The supplemented group experienced an increase in adiponectin, a hormone involved in breaking down fat and controlling blood glucose levels, and a decrease in leptin, a hormone associated with increased fat mass.
The researchers concluded that “Curcumin can improve serum levels of adiponectin and leptin in patients with metabolic syndrome.” Curcumin C3 (1 g) appears to improve two key hormones linked to obesity and diabetes https://www.ncbi.nlm.nih.gov/pubmed/27297718

Research #8
• This randomized, double-blind, placebo-controlled study examined the use of Curcumin C3 for lichen planus, an autoimmune, inflammatory condition. Twenty participants were given placebo or curcuminoids (6 g) daily for a year. The curcumin group saw significant improvements in signs and symptoms of the condition.
The researchers concluded that “Curcuminoids at doses of 6000 mg/d in 3 divided doses are well tolerated and may prove efficacious in controlling signs and symptoms of oral lichen planus.” Curcumin C3 (6 g) may alleviate inflammatory autoimmune condition lichen planus https://www.ncbi.nlm.nih.gov/pubmed/21907450

NIGELLA SATIVA THYMOQUINONE
Human studies of black cumin are still few in number, but so far report efficacy in alleviating inflammation and autoimmunity-related conditions such as allergies, asthma, and Hashimoto’s thyroiditis.

In vivo and in vitro studies have shown nigella seed powder and oil to have antibacterial, antifungal, antihistaminic, antihypertensive, anti-inflammatory, antinociceptive, antioxytocic, antiparasitic, antiviral, diuretic, hematological, hepatoprotective, hypoglycemic, immunopotentiating, wound-healing, and respiratory-stimulant properties.

At least 38 clinical studies have investigated N. sativa seed and seed oil for their efficacy for various conditions, including respiratory, diabetic, hepatic, metabolic, mental, and dyspeptic disorders, male infertility, and others.

One 2017 study explored the effects of cold-pressed Nigella Sativa Oil (NSO) with 0.7% thymoquinone on subjects with asthma. For four weeks, participants took either 500 mg of NSO twice daily or placebo. Compared to placebo, the NSO group showed a significant improvement in mean Asthma Control Test scores, as well as a significant reduction in blood eosinophils, which play a major role in asthma inflammation. There was a trend toward improved pulmonary function and peak expiratory flow in the NSO group …

Another study published in 2008, evaluated the effects of a boiled aqueous extract of nigella seed on subjects with respiratory symptoms including chest tightness, breathlessness, cough, and wheezing as a result of chemical inhalation. Significant improvements in all symptoms were seen in the Nigella Sativa group at visits at 30 days and 60 days compared to baseline, except for morning wheeze and cough at day 30. All symptoms were significantly improved by the end of the study.

Six additional studies have investigated the effects of nigella on respiratory issues. Three of these studies addressed allergic rhinitis: One study found no significant improvement and two found significant improvement in symptoms. One study on lower respiratory tract illness in children reported significant improvement. Finally, one study found that nasal dryness, obstruction, and crusting improved significantly with NSO treatment compared to a saline solution.

Reference

(Engels, 2017). The Journal of the American Botanical Council: Nigella Sativa. Retrieved 05/26/20 online from http://cms.herbalgram.org/herbalgram/issue114/hg114-herbprofile.html?ts=1586307878&signature=4aeaa97d9bd173d9b42776ce734dc93f

Research #1
• In this investigation, researchers performed four separate clinical studies testing the effects of black cumin on allergic conditions. A total of 152 people with allergies (allergic rhinitis, bronchial asthma, or atopic eczema) were given Nigella sativa oil (40 – 80 mg/kg body weight) daily. Participants in all four studies reported improvements in allergy symptoms.
The researchers concluded that “Black seed oil therefore proved to be an effective adjuvant for the treatment of allergic diseases.” https://supplementsinreview.com/immune/black-cumin-immune/

Research #2
• Black cumin oil (40 – 80 mg/kg) may alleviate allergic conditions
In this double-blind, placebo-controlled trial, 66 people with allergic rhinitis were given placebo or black cumin oil daily for 30 days. The cumin group experienced a reduction in nasal congestion, itching, runny nose, sneezing, and other symptoms for the first 15 days.
The researchers concluded that “sativa should be considered for treating allergic rhinitis when the effects of other antiallergic drugs need to be avoided.” https://supplementsinreview.com/immune/black-cumin-immune/

Research #3
• Black cumin may help with allergic rhinitis
In this placebo-controlled study, 29 people with asthma were given placebo or black cumin seed extract (15 ml/kg body weight) daily for 3 months. Compared to placebo, the cumin group saw improvement of all asthma symptoms, and had to use inhalers and asthma medications less.
The researchers concluded that “The results of phase I study generally suggest a prophylactic effect of N. sativa on asthma disease and warrant further research regarding this effect.” https://supplementsinreview.com/immune/black-cumin-immune/

Research #4
• Black cumin may alleviate asthma
This randomized, double-blind study examined the benefits of black cumin for Hashimoto’s thyroiditis, an autoimmune thyroid disorder. Forty people with the condition were given placebo or black cumin powder daily for 8 weeks. The sativa group saw reductions in body weight and BMI and improvements in thyroid-related measures such as T3 and thyroid stimulating hormone levels.
The researchers concluded that “Considering observed health- promoting effect of this medicinal plant in ameliorating the disease severity, it can be regarded as a useful therapeutic approach in management of Hashimoto’s thyroiditis. https://supplementsinreview.com/immune/black-cumin-immune/

Research #5
• Black cumin powder may alleviate Hashimoto’s thyroiditis
In this study, 30 people with hepatitis C infection were given N. sativa (1350 mg) daily for 3 months. The supplementation improved viral load (amount of virus in the body), total antioxidant capacity, lower-limb edema, and other health measures.
The researchers concluded that “sativa administration in patients with HCV was tolerable, safe, decreased viral load, and improved oxidative stress, clinical condition and glycemic control in diabetic patients.”
Black cumin (1350 mg oil) may help fight hepatitis C https://www.thyroid.org/patient-thyroid-information/ct-for-patients/september-2016/vol-9-issue-9-p-7-8/

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